我院博士生王挺等研究团队的研究成果发表在国际学术期刊上

        我院2010级博士生王挺和徐光兴及其研究团队论文《益气养心中药联合认知疗法治疗广泛性焦虑症的临床研究》。（Efficacy of Yiqiyangxin Chinese medicine compound combined with cognitive therapy in the treatment of generalized anxiety disorders）近期已发表于国际期刊《亚太热带医学杂志》（Asian Pacific Journal of Tropical Medicine）第2012,5(10)期，Doi:10.1016/s1995-7645(12)60150-3。该杂志被SCI收录，主要刊发来自热带医学及其相关学科的病理学、生物学、流行病学等方面的基础、临床研究成果，开设基础研究、临床研究、病例报告、临床经验、学术讨论等不同学科的专栏，其2011年影响因子为0.371.

        本研究对门诊202例GAD患者随机分成对照组(帕罗西汀联合认知疗法)和治疗组(益气养心中药联合认知疗法)，分别于治疗前、治疗3个月和6个月后以及停药6个月后检测患者汉密尔顿焦虑量表（HAMA）、Zung焦虑自评量表（SAS）总分、血常规、尿常规、肝肾功能、心电图，并在停药6个月后临床观察患者病情复发情况，以观察益气养心中药联合认知疗法治疗广泛性焦虑症(GAD)的临床疗效。结果表明：对照组与治疗组的HAMA和SAS评分在治疗后显著降低（P<0.001），但两组之间的HAMA和SAS评分、显效率和有效率方面无显著性差异（P＞0.05）；停药后对照组HAMA和SAS评分显著增加（P<0.05），两组在HAMA和SAS评分、病情反复和不良反应方面呈显著差异（P<0.001），治疗组临床上出现病情反复和不良反应的较少；两组血常规、尿常规、肝肾功能、心电图检查无明显异常。研究提示：益气养心中药联合认知疗法治疗GAD能明显减少停药后病情复发，不良反应少，该治疗方案有一定的推广价值。

 

 

附：

 http://www.sciencedirect.com/science/journal/19957645/5

 

Impact Factor:
2011: 0.371
 

Efficacy of Yi-Qi-Yang-Xin Chinese Herb Combined with Cognitive Therapy in the Treatment of Generalized Anxiety Disorders

Ting Wang¹, Jingyuan Ding ², Guanxing Xu¹, Yu Zeng³, Sanrong Xiao^3*

 

¹School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, P.R.China

²East China Sanatorium,Wuxi, 214065 , P.R.China

³Department of Management，Hainan Medical University，Haikou, 571101, P.R.China

 

ABSTRACT

Objective: To observe the clinical efficacy of Yi-Qi-Yang-Xin (Y-Q-Y-X) Chinese Herbal Medicine combined with cognitive therapy on generalized anxiety disorders. Methods: 202 generalized anxiety disorders (GAD) patients were randomly allocated to a control condition (Paroxetine combined with cognitive therapy) or a treatment condition (Y-Q-Y-X Chinese Herbal Medicine combined with cognitive therapy). Subsequently, we detect the patients’ scores of Hamilton Anxiety Scale (HAMA), Zung Self-rating Anxiety Scale (SAS) and blood routine, urine routine, liver function, renal function, electrocardiogram. In the detection time order, we chose before treatment, treatment for 3 months, treatment for 6 months and stopped taking the medicine after 6 months, respectively.  Results: Control group and treatment group of HAMA and SAS scores significantly reduced (P<0.001) after treatment, but the two groups between HAMA and SAS scores, apparent effect and effectiveness have no significantly differences (P>0.05). The control group HAMA and SAS scores significantly increased (P<0.05) after stopping taking the medicine. The two groups in HAMA and SAS scores, recurrent disease and adverse reaction have significantly differences (P<0.001). The treatment group has less emergenced in recurrent disease and adverse reaction in the clinic. The two groups examination in blood routine, urine routine, liver and renal function, electrocardiogram showed no apparent abnormality. Conclusion: Y-Q-Y-X Chinese Herbal Medicine combined with cognitive therapy in the treatment of GAD can significantly reduce the recurrence after stopping taking the medicine. Furthermore, fewer adverse reactions can be occurred. The treatment program has a certain promotion value and it also can be applied to the clinic in the further.

Keywords

Yi-Qi-Yang-Xin Chinese Herbal Medicine, Cognitive Therapy, Generalized Anxiety Disorder