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冯国平  博士 冯国平 博士



Research directions: 
    (1) Dissect synaptic and circuitry mechanisms of abnormal behaviors in psychiatric disorders; (2) Develop cutting-edge genetic tools for studying synaptic and circuitry function and dysfunction.
    1.Feng, G., Deak, P., Chopra, M. and Hall, L.M. (1995) Cloning and functional analysis of tipE: A novel membrane protein which enhances Drosophila para sodium channel function. Cell  82:1001-1011.
    2.Feng*, G., Tintrup*, H., Kirsch, J., Nichol, M., Kuhse, J., Betz, H. and Sanes, J.R. (1998)  Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.  Science 282:1321-1324. *co-first authors
    3.Feng, G., Hood, R., Bernstein, M., Keller-Peck, C., Nguyen, Q., Wallace, M., Nerbonne, J.M., Litchman, J.W. and Sanes, J.R  (2000). Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.  Neuron  28:41-51.
    4.Parker, M.J., Zhao, S., Bredt, D.S.,  Sanes, J.R., and Feng, G. (2004) PSD93 regulates synaptic stability at neuronal cholinergic synapses. J. Neurosci. 24:378-88. 
    5.Finn, A.J., Feng*, G., and Pendergast*, A.M. (2003) Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. Nat. Neurosci. 6:717-23. *co-corresponding authors.
    6.Young, P., Nie, J., Wang, X., McGlade, CJ, Rich, MM, and Feng, G. (2005) Interaction of ErbB2 with LNX1 E3 ubiquitin ligase:  potential role in the development of perisynaptic Schwann cells at the neuromuscular junction.  Mol. Cell. Neurosci. 30:238-48.
    7.Ficklin, MB., Zhao, S., and Feng, G. (2005) Ubiquilin-1 regulates nicotine-induced upregulation of neuronal nicotinic acetylcholine receptors.  J. Biol. Chem. 280:34088-34095.
    8.Wang, H., Peca, J., Matsusaki, M., Matsusaki, K., Noguchi, J., Qiu, L., Wang, D., Zhang, F., Boyden, E., Deisseroth, K., Kasai, H., Hall, WC., Feng*, G., and Augustine*, GJ (2007) High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice.  Proc Natl Acad Sci U S A. 104:8143-8148. *co-corresponding authors
    9.Arenkiel, B.A., Peca, J., Davison, I.G., Feliciano, C., Deisseroth, K., Augustine, G.J., Ehlers, M.D., and Feng, G. (2007) Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2.  Neuron  54:205-218.  
    10.Lu, Z, Je, H-S., Young, P., Groos, J., Lu, B., and Feng, G. (2007) Regulation of Synaptic Growth and Maturation by a Synapse-Associated E3 Ubiquitin Ligase at the Neuromuscular Junction. J Cell Biol. 177:1077-1089. 
    11.Welch, JM., Lu, J., Rodriguiz, RM., Trotta, NC., Peca, J., Ding, J-D., Feliciano, C., Chen, M., Adams, JP., Luo, J., Dudek, SM., Weinberg, RJ., Calakos, N., Wetsel, WC., and Feng, G.  (2007) Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice.  Nature  448:894-900. 
    12.Young, P., Qiu, L., Wang, D., Zhao, S., Gross, J., and Feng, G. (2008). Single-neuron labeling with inducible cre-mediated knockout in transgenic mice. Nature Neurosci. 11:721-8. 
    13.Peca J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TY, Lascola CD, Fu Z and Feng G. (2011) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature, 472:437-42.  
    14.Halassa MM, Siegle JH, Ritt JT, Ting JT, Feng* G, Moore* CI. (2011) Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles. Nat Neurosci. 14:1118-20. *co-corresponding authors.
    15.zhao, S., Ting, JT., Atallah HE., Qiu, L., Tan, J., Gloss, B., Augustine, GJ., Deisseroth, K., Luo, M., Graybiel, AM. and  Feng, G. (2011) Cell-type Specific Optogenetic Mice for Dissecting Neural Circuitry Function. Nature Methods 8:745-752. 
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